Comment on

• Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.

  Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Cheng T, et al. Nat Med. 2003 Mar;9(3):338-42. doi: 10.1038/nm826. Epub 2003 Feb 3. Nat Med. 2003. PMID: 12563316
• The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

  Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. Isermann B, et al. Nat Med. 2003 Mar;9(3):331-7. doi: 10.1038/nm825. Epub 2003 Feb 10. Nat Med. 2003. PMID: 12579195