Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Mar-Apr;17(2):105-7.
doi: 10.1016/s1056-8727(02)00185-x.

Leptin treatment ameliorates anxiety in ob/ob obese mice

Akihiro Asakawa  1 , Akio Inui, Toshio Inui, Goro Katsuura, Masayuki A Fujino, Masato Kasuga
Affiliations

Leptin treatment ameliorates anxiety in ob/ob obese mice

Akihiro Asakawa et al. J Diabetes Complications. 2003 Mar-Apr.

Abstract

We investigated whether or not administered leptin influences anxiety-like behavior in ob/ob mice. Repeated intraperitoneal administrations of leptin were continued for 5 days. Anxiety was assessed in the standard elevated plus maze. Body weight was measured daily. Repeated administrations of leptin significantly increased the percentage of the total number of entries in the open arms and the number of total entries. The body weight was significantly reduced by 13.2% after treatment. Leptin treatment ameliorated not only obesity but also anxiety in ob/ob mice. Our results indicate that the treatment of obesity may lead to the solution of psychological problems.

PubMed Disclaimer