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Comparative Study
. 2003 Mar 18;254(1):59-64.
doi: 10.1016/s0378-5173(02)00683-x.

Influence of methyl-beta-cyclodextrin and liposomes on rheological properties of Carbopol 974P NF gels

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Comparative Study

Influence of methyl-beta-cyclodextrin and liposomes on rheological properties of Carbopol 974P NF gels

Laïla Boulmedarat et al. Int J Pharm. .

Abstract

The influence of positively-charged and sterically stabilized liposomes and/or methyl-beta-cyclodextrin on rheological properties of Carbopol 974P NF hydrogels was investigated. All formulations have displayed a shear-thinning behavior of Carbopol gels, and the rate stress as a function of the shear rate was fitted using the Cross equation. An important loss of viscosity was observed when 1.5% Carbopol gels were formed in Hepes/NaCl buffer or in a 5% aqueous solution of methyl-beta-cyclodextrin. Nevertheless, when methyl-beta-cyclodextrin was dissolved in buffer at 5% there was no additional effect on gel viscosity reduction. The incorporation of positively-charged and sterically stabilized liposomes at 2 mM of lipid concentration had no incidence on rheological properties of the Carbopol gels, whereas gel viscosity was significantly increased in the presence of positively-charged liposomes at 10 mM of lipid concentration. Finally, the viscosity of hydrogels containing both liposomes and methyl-beta-cyclodextrin tended to be close to control gels, remaining high and relevant for a topical delivery.

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