Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2003 Mar 3;197(5):543-7.
doi: 10.1084/jem.20022210.

VDJ recombination: Artemis and its in vivo role in hairpin opening

Affiliations
Comment

VDJ recombination: Artemis and its in vivo role in hairpin opening

Jorge Mansilla-Soto et al. J Exp Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic representation of protein–DNA complexes in VDJ recombination. Blue and yellow rectangles represent the coding segments to be recombined (exemplified as Vλ and Jλ). The 12-RSS and 23-RSS are represented as white and black triangles, respectively. The red rectangle represents the newly generated nucleotide sequence at coding junction and the gray represents protein complexes.

Comment on

References

    1. Rooney, S., F.W. Alt, D. Lombard, S. Whitlow, M. Eckersforff, J. Fleming, S.D. Fugmann, D.O. Ferguson, D. Schatz, and J. Sekiguchi. 2002. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J. Exp. Med. 197:553–565. - PMC - PubMed
    1. Rooney, S., J. Sekiguchi, C. Zhu, H.-L. Cheng, J. Manis, S. Whitlow, J. DeVido, D. Foy, J. Chaudhuri, D. Lombard, et al. 2002. Leaky scid phenotype associated with defective V(D)J coding end processing in artemis-deficient mice. Mol. Cell. 10:1379–1390. - PubMed
    1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature. 302:575–581. - PubMed
    1. Bassing, C.H., W. Swat, and F.W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109:S45–S55. - PubMed
    1. Fugmann, S.D., A.I. Lee, P.E. Shockett, I.J. Villey, and D.G. Schatz. 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18:495–527. - PubMed

Publication types