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. 2003 Mar 3;4(2-3):147-54.
doi: 10.1002/cbic.200390025.

Polyglycine II nanosheets: supramolecular antivirals?

Alexander B Tuzikov  1 , Alexander A Chinarev, Alexandra S Gambaryan, Vladimir A Oleinikov, Dmitry V Klinov, Nadezhda B Matsko, Vasily A Kadykov, Mikhail A Ermishov, Il'ya V Demin, Victor V Demin, Phil D Rye, Nicolai V Bovin
Affiliations

Polyglycine II nanosheets: supramolecular antivirals?

Alexander B Tuzikov et al. Chembiochem. .

Abstract

Tetraantennary peptides [glycine(n)-NHCH(2)](4)C can form stable noncovalent structures by self-assembly through intermolecular hydrogen bonding. The oligopeptide chains assemble as polyglycine II to yield submicron-sized, flat, one-molecule-thick sheets. Attachment of alpha-N-acetylneuraminic acid (Neu5Acalpha) to the terminal glycine residues gives rise to water-soluble assembled glycopeptides that are able to bind influenza virus multivalently and inhibit adhesion of the virus to cells 10(3)-fold more effectively than a monomeric glycoside of Neu5Acalpha. Another antiviral strategy based on virus-promoted assembly of the glycopeptides was also demonstrated. Consequently, the self-assembly principle offers new perspectives on the design of multivalent antivirals.

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