Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Nov;2(1-2):17-22.
doi: 10.1016/s0925-4773(02)00350-7.

Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development

David R Natale  1 , Andrew J Watson
Affiliations

Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development

David R Natale et al. Gene Expr Patterns. 2002 Nov.

Retraction in

  • Retraction.
    [No authors listed] [No authors listed] Mech Dev. 2002 Dec;119 Suppl 1:S5-10. doi: 10.1016/s0925-4773(03)00085-6. Mech Dev. 2002. PMID: 14524327 No abstract available.

Abstract

Adherens junction formation is fundamental for compaction and trophectoderm differentiation during mammalian preimplantation development. We recently isolated an IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine preimplantation developmental stages. IQGAP-1 and -2 proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation development. IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources