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. 2002 Nov;2(1-2):133-6.
doi: 10.1016/s0925-4773(02)00303-9.

Integrin expression patterns during early limb muscle development in the mouse

Fernanda Bajanca  1 , Sólveig Thorsteinsdóttir
Affiliations

Integrin expression patterns during early limb muscle development in the mouse

Fernanda Bajanca et al. Gene Expr Patterns. 2002 Nov.

Retraction in

  • Retraction.
    [No authors listed] [No authors listed] Mech Dev. 2002 Dec;119 Suppl 1:S5-10. doi: 10.1016/s0925-4773(03)00085-6. Mech Dev. 2002. PMID: 14524327 No abstract available.

Abstract

Cell-extracellular matrix interactions play crucial roles in limb muscle development but practically nothing is known on what integrins are involved before the differentiation of muscle precursor cells (MPCs) in the limb muscle masses. In this study we determine the expression patterns of integrins during early forelimb muscle development in the mouse. alpha6beta1 integrin is downregulated in the lateral dermomyotome when delamination of MPCs occurs. In late E9.5 embryos, alpha1beta1 and alpha5beta1 are expressed in a pattern very similar to pax3, which marks MPCs migrating to the limb bud. After myf5 upregulation in the limb bud, alpha1beta1 and alpha5beta1 expression is maintained and the alpha4beta1 integrin starts being expressed.

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