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Comparative Study
. 2003 Mar 10;13(5):833-5.
doi: 10.1016/s0960-894x(03)00002-7.

Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin

Yann Ferrand  1 , Ludovic Bourré, Gérard Simonneaux, Sonia Thibaut, Fabrice Odobel, Y Lajat, Thierry Patrice
Affiliations
Comparative Study

Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin

Yann Ferrand et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and characterization of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin is reported. The phototoxicity on C6 cell lines and the pharmacokinetics are also reported as preliminary results showing a very high tumor to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.

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