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. 2003 Mar 10;13(5):943-6.
doi: 10.1016/s0960-894x(02)01066-1.

Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines

Sarah Chackal  1 , Michael Facompré, Raymond Houssin, Jean-François Goossens, Nicole Pommery, Jean-Pierre Hénichart, Christian Bailly
Affiliations

Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines

Sarah Chackal et al. Bioorg Med Chem Lett. .

Abstract

Several benzo[c]pyrido[2,3,4-kl]acridines bearing different substituents on the A and E rings were synthesized and evaluated for their capacity to bind to DNA and to inhibit DNA topoisomerases. Potent cytotoxic compounds were discovered but no strict correlation with their DNA binding affinity and effects on topoisomerases were observed. DNA is one but not the unique target of these compounds.

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