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. 2003 Mar 10;13(5):947-50.
doi: 10.1016/s0960-894x(02)01080-6.

Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

Stéphane Angenault  1 , Sylvie Thirot, Frédéric Schmidt, Claude Monneret, Bruno Pfeiffer, Pierre Renard
Affiliations

Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy

Stéphane Angenault et al. Bioorg Med Chem Lett. .

Abstract

A glucuronide-based prodrug of SN-38 (7-ethyl-10-hydroxycamptothecin) has been synthesized for use in a Prodrug MonoTherapy Strategy (PMT). Since this prodrug is significantly less cytotoxic than SN-38 itself and efficiently releases the drug in vitro in the presence of beta-D-glucuronidase, it can be considered as an appropriate candidate for cancer treatment by a PMT strategy.

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