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Case Reports
. 2003 Apr;36(4):402-5.
doi: 10.1002/gcc.10174.

t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

José L Vizmanos  1 , María J Larráyoz, Idoya Lahortiga, Filomena Floristán, Carmen Alvarez, María D Odero, Francisco J Novo, María J Calasanz
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Free article
Case Reports

t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

José L Vizmanos et al. Genes Chromosomes Cancer. 2003 Apr.
Free article

Abstract

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.

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