Osprey: a network visualization system

Abstract

We have developed a software platform called Osprey for visualization and manipulation of complex interaction networks. Osprey builds data-rich graphical representations that are color-coded for gene function and experimental interaction data. Mouse-over functions allow rapid elaboration and organization of network diagrams in a spoke model format. User-defined large-scale datasets can be readily combined with Osprey for comparison of different methods.

Figure 1

Representative Osprey network with genes colored by GO process and interactions colored by experimental system.

Figure 2

Searches and filters. (a) Network containing 2,245 vertices and 6,426 edges from combined datasets of Gavin et al. [10], shown in red, and Ho et al. [11], shown in yellow. (b) A source filter reveals only those interactions shared by both datasets, namely 212 vertices and 188 edges.

Figure 3

Layout options in Osprey. (a) Circular; (b) concentric circle with five rings; (c) dual ring with highly connected nodes on the inside; (d) dual ring with highly connected nodes outside; (e) spoked dual ring.