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. 2003 Mar 15;12(6):595-600.

cDNA microarray analysis of individual Duchenne muscular dystrophy patients

Satoru Noguchi  1 , Toshifumi Tsukahara, Masako Fujita, Rumi Kurokawa, Masaji Tachikawa, Tatsushi Toda, Atsumi Tsujimoto, Kiichi Arahata, Ichizo Nishino
Affiliations
  • PMID: 12620965

cDNA microarray analysis of individual Duchenne muscular dystrophy patients

Satoru Noguchi et al. Hum Mol Genet. .

Abstract

We have developed a novel cDNA microarray encompassing 3500 genes expressed in skeletal muscle. With this system, we have performed the first study of gene expression in samples from individual patients. We analyzed muscle specimen from individuals with Duchenne muscular dystrophy to identify differences among patients. Among the variably expressed genes, we focused on the expression of the genes encoding HLA-related proteins, myosin light chains and troponin Ts as markers of muscle necrosis and regeneration. The expression patterns of these genes correlated with the severity of dystrophic changes on histological examination. Our cDNA microarray provides a new tool to investigate molecular muscle pathology.

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