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. 2003 Mar;18(3):342-345.
doi: 10.1002/mds.10331.

Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis

Joong-Seok Kim  1 , Kwang-Soo Lee  1 , Si-Ryung Han  1 , Yong-An Chung  2
Affiliations

Decreased striatal dopamine transporter binding in a patient with extrapontine myelinolysis

Joong-Seok Kim et al. Mov Disord. 2003 Mar.

Abstract

We describe the case of a 61-year-old woman who developed extrapontine myelinolysis (EPM) with parkinsonism. Decreased striatal dopamine transporter binding assessed by [(123)I]N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane and single photon emission computed tomography ([(123)I]IPT) SPECT) were observed in the patient, suggesting that osmotic injury causes the demyelination of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of EPM with parkinsonism.

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References

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