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Comparative Study
. 2002 May;40(5):546-54.

Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice

Maheep Bhatnagar  1 , Pratima Rao, Jain Sushma, Rekha Bhatnagar
Affiliations
  • PMID: 12622200
Comparative Study

Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice

Maheep Bhatnagar et al. Indian J Exp Biol. 2002 May.

Abstract

Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.

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