Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers
Affiliations
- PMID: 12622246
Item in Clipboard
Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers
Pharmazie.
2003 Jan.
Abstract
The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting beta-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compounds evaluated showed weak antiisoprenaline (beta-adrenergic receptor blocking) activity and antiarrhythmic (antiouabain) activity.
Similar articles
-
Derivatives related to betaxolol with alpha- and beta-adrenergic activities.Arzneimittelforschung. 1985;35(9):1357-67. Arzneimittelforschung. 1985. PMID: 2867769
-
Beta-adrenoceptor studies. 1. In vitro beta-adrenergic blocking, antiarrhythmic, and local anesthetic activities of a new series of aromatic bis(2-hydroxy-3-isopropylaminopropyl) ethers.J Med Chem. 1974 May;17(5):507-13. doi: 10.1021/jm00251a007. J Med Chem. 1974. PMID: 4151492 No abstract available.
-
Synthesis and pharmacological activity of some 1-alkylamino-3-(2'-methoxy-4'-diethylcarbamoyl-phenoxy)propan-2-ols.Farmaco Sci. 1983 Mar;28(3):173-86. Farmaco Sci. 1983. PMID: 6133779
-
Beta-blockers as antiarrhythmic agents.Handb Exp Pharmacol. 2006;(171):235-66. Handb Exp Pharmacol. 2006. PMID: 16610347 Review.
-
Recent beta-adrenoreceptor stimulants.Adv Drug Res. 1970;5:197-253. Adv Drug Res. 1970. PMID: 4395724 Review. No abstract available.
Cited by
-
Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts.Molecules. 2016 Jun 1;21(6):707. doi: 10.3390/molecules21060707. Molecules. 2016. PMID: 27258242 Free PMC article.
-
Synthesis and biological evaluation of 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates.ScientificWorldJournal. 2013 Oct 29;2013:274570. doi: 10.1155/2013/274570. eCollection 2013. ScientificWorldJournal. 2013. PMID: 24288475 Free PMC article.
-
Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts.Molecules. 2017 Nov 23;22(12):2048. doi: 10.3390/molecules22122048. Molecules. 2017. PMID: 29168793 Free PMC article.