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. 2003 Jan;58(1):29-31.

Determination of diclofenac in pharmaceutical preparations using a novel PVC membrane sensor

S S M Hassan  1 , W H Mahmoud, M A F Elmosallamy, M H Almarzooqi
Affiliations
  • PMID: 12622249

Determination of diclofenac in pharmaceutical preparations using a novel PVC membrane sensor

S S M Hassan et al. Pharmazie. 2003 Jan.

Abstract

A novel potentiometric PVC membrane sensor for determination of diclofenac in pharmaceutical preparations has been developed. The sensor is based on the use of the 2,4,6-tri(2-pyridyl)-s-triazine iron(II) diclofenac complex [diclofenac-TPTZ-Fe(II)] as an electroactive material in a plasticized PVC membrane matrix. The sensor exhibits fast, stable and near Nernstian response for diclofenac over the concentration range 10(-2)-10(-6) M and pH 5.5-9.5. Application to quality control analysis of diclofenac in various dosage forms shows an average recovery of 99% with a mean standard deviation of 0.2%. No significant interferences are caused by inorganic and organic anions and various drug excipients and diluents.

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