SET-ting the stage for life and death
- PMID: 12628178
- DOI: 10.1016/s0092-8674(03)00151-x
SET-ting the stage for life and death
Abstract
Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
Comment on
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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.Cell. 2003 Mar 7;112(5):659-72. doi: 10.1016/s0092-8674(03)00150-8. Cell. 2003. PMID: 12628186
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