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Review
. 2003 Mar 7;112(5):591-3.
doi: 10.1016/s0092-8674(03)00152-1.

The histone minority report: the variant shall not be silenced

Fred van Leeuwen  1 , Daniel E Gottschling
Affiliations
Review

The histone minority report: the variant shall not be silenced

Fred van Leeuwen et al. Cell. .

Abstract

In this issue of Cell, Meneghini et al. demonstrate that replacement of canonical histone H2A with the histone variant H2A.Z within euchromatin prevents silent chromatin proteins from migrating into regions of the chromosome that normally are transcriptionally active. Thus, this highly conserved histone variant is critical for defining chromatin domains.

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