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. 2003 Mar;55(3):278-81.
doi: 10.1046/j.1365-2125.2003.01766.x.

Arylamine N-acetyltransferase-2 genotypes in the Thai population

Veerapol Kukongviriyapan  1 , Auemduan Prawan, Wichittra Tassaneyakul, Jareerat Aiemsa-Ard, Benjamart Warasiha
Affiliations

Arylamine N-acetyltransferase-2 genotypes in the Thai population

Veerapol Kukongviriyapan et al. Br J Clin Pharmacol. 2003 Mar.

Abstract

Aims: To determine the frequencies of the major arylamine- N-acetyltransferase-2 (NAT2) alleles in the Thai population.

Methods: DNA samples from 235 Thai individuals were analysed by polymerase chain reaction with restriction fragment length polymorphism assays.

Results: The frequency distribution of major NAT2 alleles, including NAT2*4, NAT2*5, NAT2*6 and NAT2*7 were 0.381 (95% CI 0.337, 0.426), 0.038 (0.023, 0.060), 0.326 (0.283, 0.370) and 0.204 (0.169, 0.244), respectively. When converted to phenotypes, the study population comprised 63.8% rapid acetylators and 36.2% slow acetylators.

Conclusions: The pattern of NAT2 alleles of Thais is similar to those of many Asian populations, although the frequency of NAT2*4 is significantly lower and NAT2*7 is higher than that of Oriental populations.

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