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Review
. 2003 Apr;52(4):598-9.
doi: 10.1136/gut.52.4.598.

Antidepressants for irritable bowel syndrome

R E Clouse  1
Affiliations
Review

Antidepressants for irritable bowel syndrome

R E Clouse. Gut. 2003 Apr.
No abstract available

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Figures

Figure 1
Figure 1
An algorithm for the initiation of antidepressants in irritable bowel syndrome (IBS). *Combined treatment with a tricyclic antidepressant (TCA) and some contemporary antidepressants will reduce hepatic metabolism of the TCA wherein TCA levels must be monitored to avoid toxicity. From Clouse and Lustman.
See this image and copyright information in PMC

References

    1. Jackson JL, O'Malley PG, Tomkins G, et al. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000;108:65–72. - PubMed
    1. Jailwala J, Imperiale TF, Kroenke K. Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med 2000;133:136–47. - PubMed
    1. Clouse RE, Prakash C, Anderson RJ, et al. Antidepressants for functional gastrointestinal symptoms and syndromes: a meta-analysis. Gastroenterology 2001;120(suppl 1):A642.
    1. Clouse RE, Lustman PJ. Antidepressants for irritable bowel syndrome. In: Camilleri M, Spiller RC, eds. Irritable Bowel Syndrome: Diagnosis and Treatment. London: WB Saunders, 2002:161–71.
    1. Clouse RE, Lustman, PJ, Geisman RA, et al. Antidepressant therapy in 138 patients with irritable bowel syndrome: A five-year clinical experience. Aliment Pharmacol Ther 1994;8:409–16. - PubMed

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