Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2003 Mar;30(3):423-6.
doi: 10.1007/s00259-002-1082-0. Epub 2003 Jan 11.

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

Claudia M Szobot  1 , Carla Ketzer, Renato D Cunha, Maria A Parente, Daniel D Langleben, Paul D Acton, Flávio Kapczinski, Luis A P Rohde
Affiliations
Clinical Trial

The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

Claudia M Szobot et al. Eur J Nucl Med Mol Imaging. 2003 Mar.

Abstract

Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ((99m)Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD.

PubMed Disclaimer

References

    1. Arch Neurol. 1993 Mar;50(3):279-84 - PubMed
    1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14494-9 - PubMed
    1. Eur J Nucl Med. 2000 Oct;27(10 ):1518-24 - PubMed
    1. Neuropsychopharmacology. 1993 Jun;8(4):377-86 - PubMed
    1. Yonsei Med J. 2001 Feb;42(1):19-29 - PubMed

Publication types

MeSH terms

LinkOut - more resources