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. 1972 Jul 7;238(5358):26-30.
doi: 10.1038/238026a0.

Altered enzymes in ageing human fibroblasts

R Holliday  1 , G M Tarrant
Affiliations

Altered enzymes in ageing human fibroblasts

R Holliday et al. Nature. .

Abstract

Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.

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