Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Nov;60(2):165-9.
doi: 10.1023/a:1020613600826.

Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature

L Delval  1 , J Klastersky
Affiliations
Review

Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature

L Delval et al. J Neurooncol. 2002 Nov.

Abstract

We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON). A deficiency of dihydropyrimidine dehydrogenase (DPD) was documented. Patients with DPD deficiency are at increased risk for developing unusual and/or severe toxicity to 5FU. We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency.

PubMed Disclaimer

References

    1. Ophthalmology. 1980 Oct;87(10):961-73 - PubMed
    1. Ann Neurol. 2001 Feb;49(2):146-54 - PubMed
    1. Ann Intern Med. 1961 Nov;55:731-41 - PubMed
    1. J Neuroophthalmol. 2001 Sep;21(3):164-7 - PubMed
    1. J Ocul Pharmacol Ther. 1997 Oct;13(5):473-7 - PubMed

Substances

LinkOut - more resources