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. 2003 Feb;24(1):165-78.
doi: 10.1088/0967-3334/24/1/312.

Quantitative analysis of bone mineral content by x-ray microtomography

A A Postnov  1 , A V Vinogradov, D Van Dyck, S V Saveliev, N M De Clerck
Affiliations

Quantitative analysis of bone mineral content by x-ray microtomography

A A Postnov et al. Physiol Meas. 2003 Feb.

Abstract

A new non-destructive method based on x-ray microtomography (micro-CT) was developed to measure calcium density in bone. X-ray micro-CT was used as a quantitative approach to acquire and reconstruct virtual cross-sections through the sample. Accurate beam-hardening correction was implemented. Grey values in the virtual cross-sections were calibrated as calcium mineral density in bone. From these cross-sections, three-dimensional models were created. Calcium content was calculated directly from images and expressed as percentage per volume and per weight. Calcium mineral density was studied by this method in a unique set of bones isolated from newts (Pleurodeles waltlii Michah) that had travelled into space. A demineralization of 10% was shown as a consequence of sustained micro-gravity.

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