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Multicenter Study
. 2003 Apr;72(4):1053-7.
doi: 10.1086/374383. Epub 2003 Mar 13.

Significant linkage of Parkinson disease to chromosome 2q36-37

Nathan Pankratz  1 , William C Nichols, Sean K Uniacke, Cheryl Halter, Alice Rudolph, Cliff Shults, P Michael Conneally, Tatiana Foroud; Parkinson Study Group
Affiliations
Multicenter Study

Significant linkage of Parkinson disease to chromosome 2q36-37

Nathan Pankratz et al. Am J Hum Genet. 2003 Apr.

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.

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Figures

Figure 1
Figure 1
Autosomal dominant multipoint LOD score plot for the 65 families with a strong family history of PD
See this image and copyright information in PMC

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References

Electronic-Database Information

    1. Applied Biosystems, http://home.appliedbiosystems.com
    1. Center for Medical Genetics, Marshfield Medical Research Foundation http://research.marshfieldclinic.org/genetics/
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for ARJP, PD, and PARK3)

References

    1. Abreu P, Greenberg DA, Hodge SE (1999) Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. Am J Hum Genet 65:847–857 - PMC - PubMed
    1. Bonifati V, Rizzu P, Van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, Van Dongen JW, Vanacore N, Van Swieten JC, Brice A, Meco G, Van Duijn CM, Oostra BA, Heutink P (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299:256–259 - PubMed
    1. de Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, Manubens-Bertran JM, Alperovitch A, Rocca WA (1997) Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson’s disease. J Neurol Neurosurg Psychiatr 62:10–15 - PMC - PubMed
    1. DeStefano AL, Lew MF, Golbe LI, Mark MH, Lazzarini AM, Guttman M, Montgomery E, et al (2002) PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study. Am J Hum Genet 70:1089–1095 - PMC - PubMed
    1. Foroud T, Uniacke SK, Liu L, Pankratz N, Rudolph A, Halter C, Shults C, Marder K, Conneally PM, Nichols WC, the Parkinson Study Group (2003) Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson Disease. Neurology 60:796–801 - PubMed

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