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Multicenter Study
. 2003 Apr;72(4):1053-7.
doi: 10.1086/374383. Epub 2003 Mar 13.

Significant linkage of Parkinson disease to chromosome 2q36-37

Nathan Pankratz  1 , William C Nichols, Sean K Uniacke, Cheryl Halter, Alice Rudolph, Cliff Shults, P Michael Conneally, Tatiana Foroud; Parkinson Study Group
Affiliations
Multicenter Study

Significant linkage of Parkinson disease to chromosome 2q36-37

Nathan Pankratz et al. Am J Hum Genet. 2003 Apr.

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.

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Figures

Figure 1
Figure 1
Autosomal dominant multipoint LOD score plot for the 65 families with a strong family history of PD
See this image and copyright information in PMC

References

Electronic-Database Information

    1. Applied Biosystems, http://home.appliedbiosystems.com
    1. Center for Medical Genetics, Marshfield Medical Research Foundation http://research.marshfieldclinic.org/genetics/
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for ARJP, PD, and PARK3)

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