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Review
. 2003 Feb 28;358(1430):303-14.
doi: 10.1098/rstb.2002.1198.

Identifying neurocognitive phenotypes in autism

Helen Tager-Flusberg  1 , Robert M Joseph
Affiliations
Review

Identifying neurocognitive phenotypes in autism

Helen Tager-Flusberg et al. Philos Trans R Soc Lond B Biol Sci. .

Abstract

Autism is a complex disorder that is heterogeneous both in its phenotypic expression and its etiology. The search for genes associated with autism and the neurobiological mechanisms that underlie its behavioural symptoms has been hampered by this heterogeneity. Recent studies indicate that within autism, there may be distinct subgroups that can be defined based on differences in neurocognitive profiles. This paper presents evidence for two kinds of subtypes in autism that are defined on the basis of language profiles and on the basis of cognitive profiles. The implications for genetic and neurobiological studies of these subgroups are discussed, with special reference to evidence relating these cognitive phenotypes to volumetric studies of brain size and organization in autism.

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References

    1. J Autism Dev Disord. 1996 Aug;26(4):389-406 - PubMed
    1. J Speech Hear Res. 1995 Aug;38(4):850-63 - PubMed
    1. Cognition. 1994 Apr-Jun;50(1-3):115-32 - PubMed
    1. Am J Hum Genet. 1995 Sep;57(3):717-26 - PubMed
    1. J Autism Dev Disord. 1998 Aug;28(4):273-8 - PubMed

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