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. 2003 Feb 24;13(4):605-8.
doi: 10.1016/s0960-894x(02)01064-8.

Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors

Robert F Kaltenbach 3rd  1 , Mona Patel, Robert E Waltermire, Gregory D Harris, Benjamin R P Stone, Ronald M Klabe, Sena Garber, Lee T Bacheler, Beverly C Cordova, Kelly Logue, Matthew R Wright, Susan Erickson-Viitanen, George L Trainor
Affiliations

Synthesis, antiviral activity and pharmacokinetics of P1/P1' substituted 3-aminoindazole cyclic urea HIV protease inhibitors

Robert F Kaltenbach 3rd et al. Bioorg Med Chem Lett. .

Abstract

A series of P1/P1' substituted cyclic urea analogues were prepared in an attempt to increase the intra-cellular antiviral potency of the nonsymmetrical 3-aminoindazoles DMP 850 and DMP 851. The effect of alkyl substitution of the P1/P1' residues on cellular antiviral potency, protein binding, resistance profile and pharmacokinetics are described.

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