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. 1976 Apr 8;260(5551):500-7.
doi: 10.1038/260500a0.

Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene

W Fiers, R Contreras, F Duerinck, G Haegeman, D Iserentant, J Merregaert, W Min Jou, F Molemans, A Raeymaekers, A Van den Berghe, G Volckaert, M Ysebaert

Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene

W Fiers et al. Nature. .

Abstract

Bacteriophage MS2 RNA is 3,569 nucleotides long. The nucleotide sequence has been established for the third and last gene, which codes for the replicase protein. A secondary structure model has also been proposed. Biological properties, such as ribosome binding and codon interactions can now be discussed on a molecular basis. As the sequences for the other regions of this RNA have been published already, the complete, primary chemical structure of a viral genome has now been established.

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