Mechanisms involved in platelet hyperactivation and platelet-endothelium interrelationships in diabetes mellitus
- PMID: 12643191
- DOI: 10.1007/s11892-002-0020-7
Mechanisms involved in platelet hyperactivation and platelet-endothelium interrelationships in diabetes mellitus
Abstract
This article discusses the recent findings about the mechanisms involved in platelet hyperactivation in diabetes mellitus. Particular attention is focused on the advances pertaining to 1) new features of platelet activation; 2) the role of calcium fluxes; 3) the role of glucose, insulin, and insulin resistance; 4) the role of nitric oxide; and 5) the role of endothelium.
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