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. 2003 Feb;26(2):147-50.
doi: 10.1007/BF02976661.

A DNA strand-nicking principle of a higher plant, Caesalpinia sappan

Woongchon Mar  1 , Hyun-Tai Lee, Kang-Hoon Je, Hye-Young Choi, Eun-Kyoung Seo
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A DNA strand-nicking principle of a higher plant, Caesalpinia sappan

Woongchon Mar et al. Arch Pharm Res. 2003 Feb.

Abstract

To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.

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