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. 2003 Mar 24;88(6):940-3.
doi: 10.1038/sj.bjc.6600805.

Tumoricidal activity of lauryl gallate towards chemically induced skin tumours in mice

E Ortega  1 , M C Sadaba, A I Ortiz, C Cespon, A Rocamora, J M Escolano, G Roy, L M Villar, P Gonzalez-Porque
Affiliations

Tumoricidal activity of lauryl gallate towards chemically induced skin tumours in mice

E Ortega et al. Br J Cancer. .

Abstract

Lauryl gallate (antioxidant food additive E-312) prevents the formation of dimethylbenzanthracene-induced skin tumours in mice, and kills, selectively, tumoral cells on established tumours. This results in total remission, after topical application of the compound on the tumoral mass, without affecting the surrounding tissue.

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Figures

Figure 1
Figure 1
Effect of different doses of LG on the regression of DMBA+PMA induced tumours. (A) 100 μg, (B) 250 μg, (C) 500 μg and (D) 500 μg on healthy skin.
Figure 2
Figure 2
Anatomopathological studies. (A) Normal skin, (B) untreated tumour, (C) treated tumour for 4 weeks with 500 μg of LG, (D) skin after tumour regression (treatment with 500 μg of LG for 8 weeks) and (E) normal skin treated with 500 μg of LG for 8 weeks.
See this image and copyright information in PMC

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