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. 2003 Mar 18;13(6):R231-3.
doi: 10.1016/s0960-9822(03)00158-1.

Fragile sites: breaking up over a slowdown

Karlene A Cimprich  1
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Free article

Fragile sites: breaking up over a slowdown

Karlene A Cimprich. Curr Biol. .
Free article

Abstract

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

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