doi: 10.1016/s0960-9822(03)00160-x.
Lamellipodia protrusion: moving interactions of vinculin and Arp2/3
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- PMID: 12646151
- DOI: 10.1016/s0960-9822(03)00160-x
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Lamellipodia protrusion: moving interactions of vinculin and Arp2/3
Curr Biol.
.
Free article
Abstract
A direct, transient interaction between vinculin and Arp2/3 is required to promote receptor-stimulated lamellipodial extension and cell spreading. Vinculin selectively recruits Arp2/3 to the leading edge of the lamellipodium, where it may couple the actin polymerization machinery to adhesion complexes to promote membrane protrusion over ruffling.
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