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. 2003 Mar;5(3):179-82.
doi: 10.1038/ncb0303-179.

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Mariann Bienz  1 , Hans Clevers
Affiliations

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

Mariann Bienz et al. Nat Cell Biol. 2003 Mar.

Abstract

Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.

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