Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Mar 10;284(1):31-53.
doi: 10.1016/s0014-4827(02)00098-8.

Epidermal growth factor receptor: mechanisms of activation and signalling

Robert N Jorissen  1 , Francesca Walker, Normand Pouliot, Thomas P J Garrett, Colin W Ward, Antony W Burgess
Affiliations
Review

Epidermal growth factor receptor: mechanisms of activation and signalling

Robert N Jorissen et al. Exp Cell Res. .

Abstract

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

PubMed Disclaimer