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Review
. 2003 May 1;61(1):31-7.
doi: 10.1016/s0920-9964(02)00224-4.

Association between a promoter variant in the monoamine oxidase A gene and schizophrenia

Erik G Jönsson  1 , Nadine Norton, Kaj Forslund, Marja Mattila-Evenden, Gunnar Rylander, Marie Asberg, Michael J Owen, Göran C Sedvall
Affiliations
Review

Association between a promoter variant in the monoamine oxidase A gene and schizophrenia

Erik G Jönsson et al. Schizophr Res. .

Abstract

Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n=133) and control subjects (n=377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (chi(2)=4.01, df=1, p<0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.

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