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. 2003 Apr;42(4):528-33.
doi: 10.1093/rheumatology/keg169.

FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study

A W Morgan  1 , V H Keyte, S J Babbage, J I Robinson, F Ponchel, J H Barrett, B B Bhakta, S J Bingham, M H Buch, P G Conaghan, A Gough, M Green, C A Lawson, C T Pease, A F Markham, W E R Ollier, P Emery, J Worthington, J D Isaacs
Affiliations

FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study

A W Morgan et al. Rheumatology (Oxford). 2003 Apr.

Abstract

Objectives: To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA).

Methods: This allelic association study examined the FcgammaRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK.

Results: The FcgammaRIIIA-158V allele was associated with both RA (P=0.02) and nodules (P=0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope.

Conclusions: We have developed a novel assay to genotype the FcgammaRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se.

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