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. 2001 Jul;8(1):P75-6.

Dystrophin in limb skeletal muscle fibers and creatinkinase leakage after acute +3 Gz acceleration in rhesus monkeys

B S Shenkman  1 , I N Belozerova, T L Nemirovskaya, S A Goncharova, L B Strogonova
Affiliations
  • PMID: 12650180

Dystrophin in limb skeletal muscle fibers and creatinkinase leakage after acute +3 Gz acceleration in rhesus monkeys

B S Shenkman et al. J Gravit Physiol. 2001 Jul.

Abstract

Intensive muscle tension induces significant blood accumulation of enzymes and structural proteins of the muscle origin. Altered macromolecular permeability of the sarcolemma is attributed to integrity of sarcolemmal cytoskeleton, mainly to dystrophin-sarcoglycan (DSG) complex. It is known that intensive tension of the antigravity extensor muscles is observed under conditions of gravitational overloading. We assumed that acute exposure to hypergravity would lead to serum accumulation of creatine phosphokinase (CK) associated with considerably altered integrity of the dystrophin layer in fibers of extensor muscles.

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