Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Mar 28;967(1-2):290-2.
doi: 10.1016/s0006-8993(02)04274-9.

Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats

Nikolaus A Werner  1 , James E Koch
Affiliations

Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats

Nikolaus A Werner et al. Brain Res. .

Abstract

Male Lewis rats (two groups of 10) received intracerebroventricular injections of either AM 630 (vehicle, 2.5, 5, 10 and 20 microg) or AM 281 (vehicle, 5, 10, 20 and 40 microg) following overnight food deprivation. The CB2 antagonist AM 630 failed to block deprivation-induced intake at 0.5, 1, 2, 4 and 6 h. The CB1 antagonist AM 281 significantly blocked intake following 20 microg (1 h) and 40 microg (1, 2, 4 and 6 h). Results are discussed with respect to cannabinoid receptor systems' involvement in ingestion and the differential pharmacological profiles of AM 630 and AM 281.

PubMed Disclaimer

Publication types

LinkOut - more resources