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Review
. 2003 Jan;8(1):107-15.
doi: 10.1023/a:1022155206928.

The nitric oxide-endothelin-1 connection

David Alonso  1 , Marek W Radomski
Affiliations
Review

The nitric oxide-endothelin-1 connection

David Alonso et al. Heart Fail Rev. 2003 Jan.

Abstract

Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.

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References

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