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. 2003 Apr;47(4):1407-9.
doi: 10.1128/AAC.47.4.1407-1409.2003.

In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis

Andrea L Crowell  1 , Kolby A Sanders-Lewis, W Evan Secor
Affiliations

In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis

Andrea L Crowell et al. Antimicrob Agents Chemother. 2003 Apr.

Abstract

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

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Figures

FIG. 1.
FIG. 1.
Comparison of metronidazole and tinidazole activities against 104 T. vaginalis isolates with clinical metronidazole resistance. The MLC was determined for each drug as described in the text. Each line represents a separate isolate and is generated by connecting the two points representing the MLCs for metronidazole and tinidazole. The MLCs, measured in micromolar concentrations, for metronidazole were consistently higher than those for tinidazole (P < 0.0001, Wilcoxon signed rank test).
FIG. 2.
FIG. 2.
Regression analysis of MLCs for metronidazole and tinidazole. The diagonal represents the line of identity, indicating equal concentrations of the two drugs. Each point represents an individual isolate. MLCs of metronidazole strongly correlated with MLCs of tinidazole (r = 0.8709, P < 0.0001).
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