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. 2003 Apr;47(4):1439-42.
doi: 10.1128/AAC.47.4.1439-1442.2003.

Tissue penetration by ertapenem, a parenteral carbapenem administered once daily, in suction-induced skin blister fluid in healthy young volunteers

T Laethem  1 , I De Lepeleire, J McCrea, J Zhang, A Majumdar, D Musson, D Rogers, S Li, M Guillaume, A Parneix-Spake, P Deutsch
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Tissue penetration by ertapenem, a parenteral carbapenem administered once daily, in suction-induced skin blister fluid in healthy young volunteers

T Laethem et al. Antimicrob Agents Chemother. 2003 Apr.

Abstract

The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 micro g/ml (the MIC at which 90% of the isolates tested are eliminated) for the entire dosing interval. The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration.

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Figures

FIG. 1.
FIG. 1.
Mean concentration profiles of ertapenem in plasma and blister fluid on the 3rd day of 1-g once-daily i.v. doses in healthy subjects.
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