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Comment
. 2003 Apr 1;100(7):3547-9.
doi: 10.1073/pnas.0830967100. Epub 2003 Mar 25.

Breast cancer stem cells revealed

John E Dick  1
Affiliations
Comment

Breast cancer stem cells revealed

John E Dick. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of the organization of the mammary gland. This model proposes that only mammary gland stem cells possess high self-renewal capacity and the developmental capacity to produce lineage-committed progenitors. The two major lineage-restricted progenitors have lost self-renewal capacity but still possess extensive proliferation and differentiation capacity. MGSC and progenitors possess the capacity for mammary gland regeneration after in vivo transplantation.
Figure 2
Figure 2
A model depicting the hierarchical organization of the breast cancer tumor. A rare and primitive breast cancer-initiating cell (BrCa-IC) maintains the breast cancer tumor. BrCa-IC possess high self-renewal capacity; however, they can also mature or differentiate into breast cancer cells that have lost the ability to sustain the tumor. Some of these cells may still possess extensive proliferative capacity indicative of a progenitor cell, but have lost the ability to sustain the tumor after transplantation. The breast cancer cells that comprise the bulk of the tumor tissue retain remnants of normal differentiation genetic programs.
See this image and copyright information in PMC

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