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. 2002 Dec;134(6):554-6.
doi: 10.1023/a:1022957011153.

Quantitative evaluation of DNA fragmentation

T S Kalinina  1 , A V Bannova, N N Dygalo
Affiliations

Quantitative evaluation of DNA fragmentation

T S Kalinina et al. Bull Exp Biol Med. 2002 Dec.

Abstract

A new method for evaluation of DNA fragmentation in tissue is based on computer-aided densitometric standardization of the sum of optical densities of DNA fragments visualized by electrophoresis (180-2500 b. p.) in comparison with the density of high molecular weight DNA in the same sample. The method allows evaluation of DNA fragmentation, an acknowledged marker of apoptosis, in the fetal rat brain and detection of increased DNA fragmentation during stress and under the effect of glucocorticoids.

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