Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2003 Feb;70(2):129-32.
doi: 10.1007/BF02723736.

Salbutamol and/or beclomethasone diproprionate in asthma

Sunita Sharma  1 , Preeti Godatwar, L R Kulkarni
Affiliations
Clinical Trial

Salbutamol and/or beclomethasone diproprionate in asthma

Sunita Sharma et al. Indian J Pediatr. 2003 Feb.

Abstract

Objective: Acute severe exacerbation of asthma is potentially life threatening and requires critical assessment and appropriate therapy. Now a days, steroids are often combined with bronchodilators for the treatment of bronchial asthma. Therefore, the present study was undertaken to compare effectiveness of beclomethasone diproprionate-salbutamol combination versus salbutamol alone by MDI (with or without spacer) in acute asthma.

Methods: A total of 57 paediatric patients (5-12 years) with acute attack of bronchial asthma attending emergency department of Indira Gandhi Medical College and Hospital was randomised to receive salbutamol (100 microg/puff) alone or with BDP (50 microg/puff) by metered dose inhaler with or without spacer. All baseline investigations were repeated one hour after the therapy.

Results: Clinical parameters indicative of severity of asthma improved statistically in all treatment groups. The increase in PEFR was better with MDI-S+B with spacer as compared to other groups, though it failed to reach statistical significance. The fall in serum potassium level is significantly more with MDI-S+B group when spacer was not used. No serious adverse effects were observed in any of the treatment groups.

Conclusions: Metered dose inhalation of BDP-salbutamol combination with spacer provides better recovery whereas fall in serum potassium with MDI-S+B suggests use of spacer and monitoring of serum potassium during treatment.

PubMed Disclaimer

References

    1. Pediatr Emerg Care. 1994 Dec;10(6):335-8 - PubMed
    1. Arch Pediatr Adolesc Med. 1994 Feb;148(2):189-94 - PubMed
    1. J Paediatr Child Health. 1996 Dec;32(6):495-7 - PubMed
    1. Arch Dis Child. 1994 Mar;70(3):170-3 - PubMed
    1. Acta Paediatr. 1995 Mar;84(3):305-7 - PubMed

Publication types