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. 2003 Apr 4;68(7):2623-32.
doi: 10.1021/jo026655v.

Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists

Alexander G Godfrey  1 , Dawn A Brooks, Lynne A Hay, Mary Peters, James R McCarthy, David Mitchell
Affiliations

Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists

Alexander G Godfrey et al. J Org Chem. .

Abstract

An improved method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.

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