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Clinical Trial
. 2003 Apr;107(4):283-90.
doi: 10.1034/j.1600-0447.2003.00087.x.

Anterior cingulotomy for refractory obsessive-compulsive disorder

C-H Kim  1 , J W Chang, M-S Koo, J W Kim, H S Suh, I H Park, H S Lee
Affiliations
Clinical Trial

Anterior cingulotomy for refractory obsessive-compulsive disorder

C-H Kim et al. Acta Psychiatr Scand. 2003 Apr.

Abstract

Objective: This study was designed to prospectively investigate the efficacy and cognitive adverse effects of stereotactic bilateral anterior cingulotomy as a treatment for refractory obsessive-compulsive (OCD) patients for 12 months.

Method: Patients were eligible if they had severe OCD and rigorous treatments had been unsuccessful. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Clinical Global Impression (CGI) and neuropsychological tests were used to assess the efficacy and cognitive changes of cingulotomy before and 12 months after operation.

Results: The mean improvement rate of the Y-BOCS scores achieved from baseline was 36.0%. Out of 14 patients six met responder criteria; 35% or higher improvement rate on Y-BOCS and CGI improvement of very much or much better at 12-month follow-up. There was no significant cognitive dysfunction after cingulotomy.

Conclusion: Anterior cingulotomy shows few cognitive adverse effects, with about half of the OCD patients demonstrating significant symptomatic improvement.

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