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. 2003 Apr;77(8):5037-8.
doi: 10.1128/jvi.77.8.5037-5038.2003.

A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo

Martin Markowitz  1 , Michael Louie, Arlene Hurley, Eugene Sun, Michele Di Mascio, Alan S Perelson, David D Ho
Affiliations

A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo

Martin Markowitz et al. J Virol. 2003 Apr.

Abstract

Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4(+) T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.

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Figures

FIG. 1.
FIG. 1.
HIV-1 RNA decay in the plasma of nine patients (pat) after initiation of therapy with lopinavir-ritonavir, tenofovir DF, lamivudine, and efavirenz. The best fit of measured HIV-1 RNA levels in plasma (circles) to a multicomponent model of HIV-1 RNA decay (4) (solid lines) is shown.
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References

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